home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410b.zip
/
M94A0330.TXT
< prev
next >
Wrap
Text File
|
1994-10-08
|
3KB
|
46 lines
Document 0330
DOCN M94A0330
TI Rifampin-resistant Mycobacterium kansasii.
DT 9412
AU Wallace RJ Jr; Dunbar D; Brown BA; Onyi G; Dunlap R; Ahn CH; Murphy DT;
Department of Microbiology, University of Texas Health Center,; Tyler
75710.
SO Clin Infect Dis. 1994 May;18(5):736-43. Unique Identifier : AIDSLINE
MED/94355504
AB We identified 36 rifampin-resistant Mycobacterium kansasii isolates,
including 17 (4%) of 464 isolates recovered in Texas between 1989 and
1992. Of 29 patients infected with rifampin-resistant M. kansasii whose
history of medication was known, 90% had previously received rifampin,
and 58% of these patients had been treated with one or two effective
drugs. Thirty-two percent of rifampin-resistant isolates recovered since
1989 were from patients who were seropositive for human immunodeficiency
virus (HIV) infection. Twenty courses of therapy with a four-drug
regimen determined on the basis of in vitro susceptibilities were
administered to 16 patients from whom rifampin-resistant isolates were
recovered; the therapy did not include surgery. Sputum cultures
converted to negative as the result of 90% of treatments (time to
conversion: mean, 11 weeks; range, 4-20 weeks). Bacteriologic relapses
occurred in four of five patients who withdrew from therapy after being
culture negative for < or = 6 months of therapy and in one of 12
patients who were culture negative for at least 12 months of therapy
(mean, 16.3 months). This study suggests that the prognosis for cure of
infection due to rifampin-resistant M. kansasii with chemotherapy alone
is excellent, although the number of cases appears to be increasing, in
part because of the HIV disease epidemic.
DE Adult Aged Aged, 80 and over Amikacin/ADMINISTRATION & DOSAGE
Antibiotics, Combined/*THERAPEUTIC USE Antitubercular
Agents/PHARMACOLOGY/*THERAPEUTIC USE Ciprofloxacin/ADMINISTRATION &
DOSAGE Clinical Protocols Drug Resistance, Microbial
Ethambutol/ADMINISTRATION & DOSAGE Female Human
Isoniazid/ADMINISTRATION & DOSAGE Male Middle Age Mycobacterium
Infections, Atypical/DRUG THERAPY/*EPIDEMIOLOGY/ MICROBIOLOGY
Mycobacterium, Atypical/*DRUG EFFECTS Pyrazinamide/ADMINISTRATION &
DOSAGE Pyridoxine/ADMINISTRATION & DOSAGE Rifampin/ADMINISTRATION &
DOSAGE/*PHARMACOLOGY Streptomycin/ADMINISTRATION & DOSAGE Support,
Non-U.S. Gov't Texas/EPIDEMIOLOGY Treatment Outcome Tuberculosis/DRUG
THERAPY/*EPIDEMIOLOGY/MICROBIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).